The Retrospective Study of Second‐line Chemotherapy in Ovarian Cancer
Identifieur interne : 000B80 ( Main/Exploration ); précédent : 000B79; suivant : 000B81The Retrospective Study of Second‐line Chemotherapy in Ovarian Cancer
Auteurs : Hiroshi Nishii [Japon] ; Makoto Yasuda [Japon] ; Toshiki Wachi [Japon] ; Eizo Kimura [Japon] ; Kazuhiko Ochiai [Japon] ; Kazunori Ochiai [Japon] ; Tadao Tanaka [Japon]Source :
- Journal of Obstetrics and Gynaecology Research [ 1341-8076 ] ; 2003-02.
English descriptors
- Teeft :
- Acta, Acta obst gynaec, Acta obstetrica, Blackwell science, Chemotherapy, Cumulative survival rate, Eizo, Eizo kimura, Epitherial, February, Gynaec, Gynaecol, Gynaecologica, Gynaecologica japonica, Gynaecology, Gynaecology asia, Gynecology, Hiroshi, Hiroshi nishii, Histological, Histological diagnosis, Japan objective, Japonica, Jikei, Jikei university school, Jogthe, Jogthe journal, Kaplanmeier, Kaplanmeier method, Kazuhiko, Kazuhiko ochiai, Kazunori, Kazunori ochiai, Kimura, Laparotomy, Line chemotherapy, Ltdoxford, Makoto, Makoto yasuda, Median survival time, Negative group months, Nishii, Obst, Obstet, Obstetrica, Obstetrics, Oceania federation, Ochiai, Ovarian, Ovarian cancer, Ovarian cancer hiroshi nishii, Paclitaxel, Positive group months, Retrospective study, Retrospectively, Second line chemotherapy, Sgml, Short term, Survival period, Survival rate, Survival rates, Tadao, Tadao tanaka department, Tanaka, Tokyo japan, Toshiki, Toshiki wachi, Wachi, Yasuda.
Abstract
Objective: To evaluate the efficacy of Second‐line Chemotherapy for ovarian cancer not from short term efficacy but from the survival rate.
Patients and Methods: Eighty‐seven patients with epitherial ovarian cancer treated with Second‐line chemotherapy from 1993 were examined retrospectively. All the patients were treated with platinum as first line chemotherapy (≥ 3 courses). Paclitaxel was used for Second‐line Chemotherapy in 25 patients. The Kaplan‐Meier Method and Log‐Rank Test were carried out for the cumulative survival rate and analysis.
Results: The Median Survival Time of all patients after Second‐line Chemotherapy was 23.6 months. Any significant difference in the survival rate was recognized only by the histological diagnosis (p < 0.0001). There was no significant difference in the survival rates whether patients were treated with paclitaxel as second line chemotherapy or not (p = 0.1915). The disease free survival period of the Second Look Laparotomy (SLL) negative group (23.9 months) is longer than that of SLL positive group (6.2 months).
Conclusions: The survival rate after Second‐line Chemotherapy was influenced only by histological diagnosis.
ACTA OBST GYNAEC JPN Vol. 54, No. 9, pp. 1429–1436, 2002
Url:
DOI: 10.1046/j.1341-8076.2003.00075.x
Affiliations:
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<front><div type="abstract">Objective: To evaluate the efficacy of Second‐line Chemotherapy for ovarian cancer not from short term efficacy but from the survival rate.</div>
<div type="abstract">Patients and Methods: Eighty‐seven patients with epitherial ovarian cancer treated with Second‐line chemotherapy from 1993 were examined retrospectively. All the patients were treated with platinum as first line chemotherapy (≥ 3 courses). Paclitaxel was used for Second‐line Chemotherapy in 25 patients. The Kaplan‐Meier Method and Log‐Rank Test were carried out for the cumulative survival rate and analysis.</div>
<div type="abstract">Results: The Median Survival Time of all patients after Second‐line Chemotherapy was 23.6 months. Any significant difference in the survival rate was recognized only by the histological diagnosis (p < 0.0001). There was no significant difference in the survival rates whether patients were treated with paclitaxel as second line chemotherapy or not (p = 0.1915). The disease free survival period of the Second Look Laparotomy (SLL) negative group (23.9 months) is longer than that of SLL positive group (6.2 months).</div>
<div type="abstract">Conclusions: The survival rate after Second‐line Chemotherapy was influenced only by histological diagnosis.</div>
<div type="abstract">ACTA OBST GYNAEC JPN Vol. 54, No. 9, pp. 1429–1436, 2002</div>
</front>
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