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The Retrospective Study of Second‐line Chemotherapy in Ovarian Cancer

Identifieur interne : 000B80 ( Main/Exploration ); précédent : 000B79; suivant : 000B81

The Retrospective Study of Second‐line Chemotherapy in Ovarian Cancer

Auteurs : Hiroshi Nishii [Japon] ; Makoto Yasuda [Japon] ; Toshiki Wachi [Japon] ; Eizo Kimura [Japon] ; Kazuhiko Ochiai [Japon] ; Kazunori Ochiai [Japon] ; Tadao Tanaka [Japon]

Source :

RBID : ISTEX:4A90D06CF483466677FE909F7268AE064CE5AF2E

English descriptors

Abstract

Objective:  To evaluate the efficacy of Second‐line Chemotherapy for ovarian cancer not from short term efficacy but from the survival rate.
Patients and Methods:  Eighty‐seven patients with epitherial ovarian cancer treated with Second‐line chemotherapy from 1993 were examined retrospectively. All the patients were treated with platinum as first line chemotherapy (≥ 3 courses). Paclitaxel was used for Second‐line Chemotherapy in 25 patients. The Kaplan‐Meier Method and Log‐Rank Test were carried out for the cumulative survival rate and analysis.
Results:  The Median Survival Time of all patients after Second‐line Chemotherapy was 23.6 months. Any significant difference in the survival rate was recognized only by the histological diagnosis (p < 0.0001). There was no significant difference in the survival rates whether patients were treated with paclitaxel as second line chemotherapy or not (p = 0.1915). The disease free survival period of the Second Look Laparotomy (SLL) negative group (23.9 months) is longer than that of SLL positive group (6.2 months).
Conclusions:  The survival rate after Second‐line Chemotherapy was influenced only by histological diagnosis.
ACTA OBST GYNAEC JPN Vol. 54, No. 9, pp. 1429–1436, 2002

Url:
DOI: 10.1046/j.1341-8076.2003.00075.x


Affiliations:


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<front>
<div type="abstract">Objective:  To evaluate the efficacy of Second‐line Chemotherapy for ovarian cancer not from short term efficacy but from the survival rate.</div>
<div type="abstract">Patients and Methods:  Eighty‐seven patients with epitherial ovarian cancer treated with Second‐line chemotherapy from 1993 were examined retrospectively. All the patients were treated with platinum as first line chemotherapy (≥ 3 courses). Paclitaxel was used for Second‐line Chemotherapy in 25 patients. The Kaplan‐Meier Method and Log‐Rank Test were carried out for the cumulative survival rate and analysis.</div>
<div type="abstract">Results:  The Median Survival Time of all patients after Second‐line Chemotherapy was 23.6 months. Any significant difference in the survival rate was recognized only by the histological diagnosis (p < 0.0001). There was no significant difference in the survival rates whether patients were treated with paclitaxel as second line chemotherapy or not (p = 0.1915). The disease free survival period of the Second Look Laparotomy (SLL) negative group (23.9 months) is longer than that of SLL positive group (6.2 months).</div>
<div type="abstract">Conclusions:  The survival rate after Second‐line Chemotherapy was influenced only by histological diagnosis.</div>
<div type="abstract">ACTA OBST GYNAEC JPN Vol. 54, No. 9, pp. 1429–1436, 2002</div>
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